Drug Mechanism Enrichment Analysis

Welcome! Drug Mechanism Enrichment Analysis (DMEA) is a highly versatile tool to identify drug mechanisms statistically enriched in a ranked list of drugs. It can also identify selectively toxic drug mechanisms based on an input gene signature. To get started using DMEA, please visit our How to Use page.

To learn more about DMEA, you can read our publication in BMC Bioinformatics here:

If you use DMEA, please cite:

Garana, B.B., Joly, J.H., Delfarah, A. et al. Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing. BMC Bioinformatics 24, 215 (2023).

DMEA method for drug rank list input